Antidiabetic and wound healing potential of biologically fabricated chitosan nanoparticles of aqueous seed extract of Hunteria umbellata

Background: Hunteria umbellata (HU) is a tropical rainforest shrub in the Apocynaceae family, with various medicinal properties. Nanostructured systems improve pharmacokinetic and pharmacodynamic properties of bioactive compounds. The current study evaluates antidiabetic wound healing efficacy umbellata-chitosan nanoparticles (HUCNPs). Methods: Aqueous seed extract was prepared from mature HU pods. Chitosan H. were created by ionic gelation chitosan tripolyphosphate anions (TPP) characterized using Dynamic light scattering (DLS) Fourier Transform Infrared Spectroscopy (FT-IR). streptozotocin-induced diabetic rat model excision used to investigate activity HUCNPs. Serum biochemical marker enzymes antioxidants kidney liver tissues quantified. Result: FT-IR confirmed successful cross linkage compounds nanoparticles. HUCNPs had particle size 408.6 ± 1.5 nm, zeta potential 32.4 1.6, polydispersity index 0.47. Rats treated significantly reduced mean fasting blood glucose level. levels Glutamic oxaloacetic transaminase (SGOT), glutamic pyruvic (SGPT), alkaline phosphatase closer normal than control. Catalase (CAT), glutathione (GSH), superoxide dismutase (SOD) higher HUCNPs-treated tissues, while lipid peroxidase (LPO) lower. topical application ointment accelerated (81.6 %) prevented microbial invasion surface. Conclusion: This suggests as an excellent strategy for targeted drug delivery diabetes management healing.